Depression is a mental state that affects a person’s consciousness, thinking and actions. This is not just a temporary change in mood, it is a disease that needs the help of a specialist. Stress negatively affects all aspects of a person’s life, including relationships with family, friends and others. Behavior that causes difficulties at school, school and work, up to suicide. The causes can be psycho-emotional and social factors, sometimes diseases of internal organs and nerves. Complex stresses are senesto-hypochondriac stresses. In this case, delusions, hallucinations and catatonic disorders are observed. Medium – there is a decrease in social activity with clinical symptoms. And the severe form is characterized by the predominance of this or that symptom (despondency, apathy, anxiety, anxiety), the manifestation of suicidal thoughts, inoperability. Treatment of stressful situations depends on the duration and intensity and severity of the disease. Treatment begins with prescribing one of the antidepressants for a week. If no effect is observed at this time, then the dose is first increased to the maximum level. And if there is no improvement within two weeks, the drug should be replaced with an antidepressant with a different mechanism of action.